Platelet activating factor-induced pulmonary accumulation of111indium-oxine labelled neutrophils in anesthetized guinea pigs
Identifieur interne : 000356 ( Main/Exploration ); précédent : 000355; suivant : 000357Platelet activating factor-induced pulmonary accumulation of111indium-oxine labelled neutrophils in anesthetized guinea pigs
Auteurs : RBID : ISTEX:11745_1991_Article_BF02536549.pdfAbstract
The thoracic accumulation of neutrophils labelled with111Indium-oxine in response to infusion of platelet activating factor (PAF, 18 ng/kg/min × 5 min, i.v.) was studied using an automated isotope monitoring system (AIMSplus) in anesthetized guinea-pigs. Loss of cell associated radioactivityin vitro was less than 1% over 4 hr. Labelled neutrophils maintained their functional capacity (oxidative response to the cell stimulants N-formyl-L-methionine-L-leucine-L-phenylalanine and phorbol myristate acetate) and >95% viability (ethidium bromide/acridine orange stain)in vitro. Total thoracic radioactivity increased significantly from baseline in response to PAF with a slight tachyphylaxia in the neutrophil-accumulation after a repeat PAF infusion. The highest ratios of radiolabel (tissue/blood) were found in the spleen >>liver>lung.
DOI: 10.1007/BF02536549
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Anderson</name><affiliation wicri:level="1"><mods:affiliation>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name>Madeleine Kings</name><affiliation wicri:level="1"><mods:affiliation>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name>John Morley</name><affiliation wicri:level="1"><mods:affiliation>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="RBID">ISTEX:11745_1991_Article_BF02536549.pdf</idno><date when="1991">1991</date><idno type="doi">10.1007/BF02536549</idno><idno type="wicri:Area/Main/Corpus">000473</idno><idno type="wicri:Area/Main/Curation">000473</idno><idno type="wicri:Area/Main/Exploration">000356</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The thoracic accumulation of neutrophils labelled with111Indium-oxine in response to infusion of platelet activating factor (PAF, 18 ng/kg/min × 5 min, i.v.) was studied using an automated isotope monitoring system (AIMSplus) in anesthetized guinea-pigs. Loss of cell associated radioactivityin vitro was less than 1% over 4 hr. Labelled neutrophils maintained their functional capacity (oxidative response to the cell stimulants N-formyl-L-methionine-L-leucine-L-phenylalanine and phorbol myristate acetate) and >95% viability (ethidium bromide/acridine orange stain)in vitro. Total thoracic radioactivity increased significantly from baseline in response to PAF with a slight tachyphylaxia in the neutrophil-accumulation after a repeat PAF infusion. The highest ratios of radiolabel (tissue/blood) were found in the spleen >>liver>lung.</div></front></TEI><mods xsi:schemaLocation="http://www.loc.gov/mods/v3 file:///applis/istex/home/loadistex/home/etc/xsd/mods.xsd" version="3.4" istexId="5283d1616f5a9d6fb51574d045d3b9d68fc3cc2b"><titleInfo lang="eng"><title>Platelet activating factor-induced pulmonary accumulation of111indium-oxine labelled neutrophils in anesthetized guinea pigs</title></titleInfo><name type="personal"><namePart type="given">Ursula</namePart><namePart type="family">Hultkvist-Bengtsson</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel, Switzerland</affiliation></name><name type="personal"><namePart type="given">Gary P.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel, Switzerland</affiliation></name><name type="personal"><namePart type="given">Madeleine</namePart><namePart type="family">Kings</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel, Switzerland</affiliation></name><name type="personal"><namePart type="given">John</namePart><namePart type="family">Morley</namePart><role><roleTerm type="text">author</roleTerm></role><affiliation>Preclinical Research, Sandoz AG, 386/325, CH-4002, Basel, Switzerland</affiliation></name><typeOfResource>text</typeOfResource><genre>PAF, the Respiratory System, Allergy, and Asthma</genre><genre>Original Paper</genre><originInfo><publisher>Springer-Verlag, Berlin/Heidelberg</publisher><dateCreated encoding="w3cdtf">1989-08-02</dateCreated><dateCaptured encoding="w3cdtf">1991-04-03</dateCaptured><dateValid encoding="w3cdtf">2006-11-24</dateValid><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="eng">The thoracic accumulation of neutrophils labelled with111Indium-oxine in response to infusion of platelet activating factor (PAF, 18 ng/kg/min × 5 min, i.v.) was studied using an automated isotope monitoring system (AIMSplus) in anesthetized guinea-pigs. Loss of cell associated radioactivityin vitro was less than 1% over 4 hr. Labelled neutrophils maintained their functional capacity (oxidative response to the cell stimulants N-formyl-L-methionine-L-leucine-L-phenylalanine and phorbol myristate acetate) and >95% viability (ethidium bromide/acridine orange stain)in vitro. Total thoracic radioactivity increased significantly from baseline in response to PAF with a slight tachyphylaxia in the neutrophil-accumulation after a repeat PAF infusion. The highest ratios of radiolabel (tissue/blood) were found in the spleen >>liver>lung.</abstract><relatedItem type="series"><titleInfo type="abbreviated"><title>Lipids</title></titleInfo><titleInfo><title>Lipids</title><partNumber>Year: 1991</partNumber><partNumber>Volume: 26</partNumber><partNumber>Number: 12</partNumber></titleInfo><genre>Archive Journal</genre><originInfo><dateIssued encoding="w3cdtf">1991-12-01</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><subject usage="primary"><topic>Life Sciences</topic><topic>Nutrition</topic><topic>Bioorganic Chemistry</topic><topic>Medicinal Chemistry</topic><topic>Medical Biochemistry</topic><topic>Biochemistry, general</topic><topic>Microbial Genetics and Genomics</topic></subject><identifier type="issn">0024-4201</identifier><identifier type="issn">Electronic: 1558-9307</identifier><identifier type="matrixNumber">11745</identifier><identifier type="local">IssueArticleCount: 100</identifier><recordInfo><recordOrigin>American Oil Chemists’ Society, 1991</recordOrigin></recordInfo></relatedItem><identifier type="doi">10.1007/BF02536549</identifier><identifier type="matrixNumber">Art66</identifier><identifier type="local">BF02536549</identifier><accessCondition type="use and reproduction">MetadataGrant: OpenAccess</accessCondition><accessCondition type="use and reproduction">AbstractGrant: OpenAccess</accessCondition><accessCondition type="restriction on access">BodyPDFGrant: Restricted</accessCondition><accessCondition type="restriction on access">BodyHTMLGrant: Restricted</accessCondition><accessCondition type="restriction on access">BibliographyGrant: Restricted</accessCondition><accessCondition type="restriction on access">ESMGrant: Restricted</accessCondition><part><extent unit="pages"><start>1283</start><end>1286</end></extent></part><recordInfo><recordOrigin>American Oil Chemists’ Society, 1991</recordOrigin><recordIdentifier>11745_1991_Article_BF02536549.pdf</recordIdentifier></recordInfo></mods></record>Pour manipuler ce document sous Unix (Dilib)
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